Article
Genetic association between interleukin-10 gene promoter region polymorphisms and type 1 diabetes age-at-onset.
Human immunology - 1 Aug 2002
Ide Akane, Kawasaki Eiji, Abiru Norio, Sun Fuyan, Takahashi Ryoko, Kuwahara Hironaga, Fujita Naruhiro, Kita Atsushi, Oshima Katsuya, Sakamaki Hiroyuki, Uotani Shigeo, Yamasaki Hironori, Yamaguchi Yoshihiko, Eguchi Katsumi
Abstract excerpt
This study investigated whether interleukin-10 (IL-10) gene promoter region polymorphisms are associated with susceptibility to or clinical presentation of type 1 diabetes. The frequency of -1082G/A, -819C/T, and -592C/A polymorphisms was analyzed in 128 Japanese patients with type 1 diabetes and in 107 healthy control subjects in a case-controlled study. The allelic and haplotypic frequencies of the IL-10 gene...
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