Article
Distribution of HLA class I alleles differs in celiac disease patients according to age of onset.
Digestive diseases and sciences - 1 Mar 2003
Vogelsang Harald, Panzer Simon, Mayr Wolfgang R, Granditsch Gerhard, Fischer Gottfried F
Abstract excerpt
Celiac disease (CD) or gluten-sensitive enteropathy is strongly associated with HLA-DQ alleles; more than 95% of patients are DQB1*02. However, the uniform association with HLA-DQ alleles does not explain the clinical heterogeneity, especially the wide range in the age of onset of CD. We asked whether the age of onset of CD is also influenced by class I genes of the human MHC. We performed HLA typing in three...
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