Article
Early age of disease onset in African American type 1 diabetes patients is associated with DQB1*0201 allele.
Human immunology - 1 Aug 2000
Berka N, Bland G N, Gause D P, Harris P F, Erabhaoui E H, Bonar A S, Dunston G M
Abstract excerpt
The goal of this study is to assess the association of HLA-DQ alleles with the age of onset of type 1 diabetes in African American patients. Using PCR oligonucleotide typing, HLA-DQA1 and DQB1 alleles were determined. DQA1*0301, DQB1*0201, and DQB1*0302 were significantly increased in African American patients. However, the DQB1*0602 allele was decreased in these patients. In addition, DQA1*0401 and DQB1*0402,...
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