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Article

Posttranscriptional regulation of Bruton's tyrosine kinase expression in antigen receptor-stimulated splenic B cells.

Proceedings of the National Academy of Sciences of the United States of America - 14 Mar 2000

Nisitani S, Satterthwaite A B, Akashi K, Weissman I L, Witte O N, Wahl M I

Abstract excerpt

Mutation of Bruton's tyrosine kinase (Btk) causes human X-linked agammaglobulinemia and murine X-linked immunodeficiency syndrome (xid). Quantitative aspects of B lymphocyte development and function have been demonstrated to depend on Btk level in vivo by using a murine transgenic model system. A sensitive intracellular immunofluorescent assay was developed to measure Btk protein on a per cell basis to test the...

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Identifiers

PMID: 10688914
DOI: 10.1073/pnas.050583597
PMCID: PMC15999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Posttranscriptional regulation of Bruton's tyrosine kinase expression in antigen receptor-stimulated splenic B cells.PMID 10688914Read ↗

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