Bruton tyrosine kinase is tyrosine phosphorylated and activated in pre-B lymphocytes and receptor-ligated B cells.

doi:10.1073/pnas.91.22.10606

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Article

Bruton tyrosine kinase is tyrosine phosphorylated and activated in pre-B lymphocytes and receptor-ligated B cells.

Proceedings of the National Academy of Sciences of the United States of America - 25 Oct 1994

Aoki Y, Isselbacher K J, Pillai S

Abstract excerpt

The gene encoding Bruton tyrosine kinase (Btk) is known to be mutated in human X chromosome-linked agammaglobulinemia and in the Xid mouse. This kinase was examined in B lymphocytes before and after antigen receptor ligation and also in pre-B cells. Btk was found to be catalytically activated and tyrosine phosphorylated in response to anti-IgM stimulation in B cells. This kinase is also constitutively...

Topics

Agammaglobulinaemia Tyrosine Kinase
Agammaglobulinemia
Animals
B-Lymphocytes
Cell Line
Enzyme Activation
Hematopoietic Stem Cells
Humans
Immunoglobulin M
Kinetics
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Mutant Strains

Models, Biological

Mutation

Phosphorylation

Phosphotyrosine

Protein-Tyrosine Kinases

Receptors, Antigen, T-Cell

Source

Open in PubMed Open full text

Identifiers

PMID: 7524098
DOI: 10.1073/pnas.91.22.10606
PMCID: PMC45070

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7524098-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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