Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice.

Journal of virology - 1 Jul 1994

Battegay M, Moskophidis D, Rahemtulla A, Hengartner H, Mak T W, Zinkernagel R M

Abstract excerpt

CD4+ T cells play an important role in regulating the immune response; their contribution to virus clearance is variable. Mice that lack CD4+ T cells (CD4-/- mice) and are therefore unable to produce neutralizing antibodies cleared viscero-lymphotropic lymphocytic choriomeningitis virus (LCMV) strain WE when infected intravenously with a low dose (2 x 10(2) PFU) because of an effective CD8+ cytotoxic T-cell (CTL)...

Topics

Animals
Antibodies, Viral
CD4-Positive T-Lymphocytes
Carrier State
Lymphocytic Choriomeningitis
Lymphocytic choriomeningitis virus
Mice
Mice, Inbred C57BL
Mutation
Neutralization Tests
T-Lymphocytes, Cytotoxic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 7911534
DOI: 10.1128/JVI.68.7.4700-4704.1994
PMCID: PMC236402

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7911534-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice.PMID 7911534Read ↗

Viral persistence <i>in vivo</i> through selection of neutralizing antibody-escape variantsSemantic proximity Read ↗

Exhaustion of cytotoxic T cells during adoptive immunotherapy of virus carrier mice can be prevented by B cells or CD4+ T cellsSemantic proximity Read ↗

Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytesSemantic proximity Read ↗

Lymphocytic choriomeningitis virus Clone 13 infection causes either persistence or acute death dependent on IFN-1, cytotoxic T lymphocytes (CTLs), and host geneticsSemantic proximity Read ↗

High antigen levels induce an exhausted phenotype in a chronic infection without impairing T cell expansion and survival.Semantic proximity Read ↗

Profiling Virus-Specific Tcf1+ T Cell Repertoires During Acute and Chronic Viral Infection.Semantic proximity Read ↗

Profiling virus-specific Tcf1+ T cell repertoires during acute and chronic viral infectionSemantic proximity Read ↗

Lymphocytes have a role in protection, but not in pathogenesis, during La Crosse Virus infection in miceSemantic proximity Read ↗

Underwhelming the Immune Response: Effect of Slow Virus Growth on CD8<sup>+</sup>-T-Lymphocyte ResponsesSemantic proximity Read ↗

Virus-induced immunosuppression: kinetic analysis of the selection of a mutation associated with viral persistence.Semantic proximity Read ↗

Impairment of CD4(+) T cell responses during chronic virus infection prevents neutralizing antibody responses against virus escape mutants.Semantic proximity Read ↗

Viral escape from the neutralizing antibody response: the lymphocytic choriomeningitis virus model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.