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Article

HCV persistence and immune evasion in the absence of memory T cell help.

Science (New York, N.Y.) - 24 Oct 2003

Grakoui Arash, Shoukry Naglaa H, Woollard David J, Han Jin-Hwan, Hanson Holly L, Ghrayeb John, Murthy Krishna K, Rice Charles M, Walker Christopher M

Abstract excerpt

Spontaneous resolution of hepatitis C virus (HCV) infection in humans usually affords long-term immunity to persistent viremia and associated liver diseases. Here, we report that memory CD4+ Tcells are essential for this protection. Antibody-mediated depletion of CD4+ Tcells before reinfection of two immune chimpanzees resulted in persistent, low-level viremia despite functional intra-hepatic memory CD8+ Tcell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14576438
DOI: 10.1126/science.1088774

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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