Article
Single amino acid substitution in the Fc region of chimeric TNT-3 antibody accelerates clearance and improves immunoscintigraphy of solid tumors.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 1 Feb 2000
Hornick J L, Sharifi J, Khawli L A, Hu P, Bai W G, Alauddin M M, Mizokami M M, Epstein A L
Abstract excerpt
UNLABELLED: Recent studies in antibody catabolism have identified residues at the CH2-CH3 interface of the IgG heavy chain critical for serum persistence of immunoglobulins. Amino acid substitutions in the Fc region of murine IgG1 were shown to drastically accelerate antibody clearance in mice. Our laboratory has previously described a human-mouse chimeric TNT-3 (chTNT-3) monoclonal antibody directed against a...
Topics
- Adenocarcinoma
- Amino Acid Substitution
- Animals
- Antibodies, Monoclonal
- Colonic Neoplasms
- Female
- Humans
- Iodine Radioisotopes
- Male
- Mice
- Mice, Nude
- Mutation
- Neoplasm Transplantation