Article
Global conformational changes in IgG-Fc upon mutation of the FcRn-binding site are not associated with altered antibody-dependent effector functions.
The Biochemical journal - 5 Jul 2018
Burvenich Ingrid J G, Farrugia William, Liu Zhanqi, Makris Dahna, King Dylan, Gloria Benjamin, Perani Angelo, Allan Laura C, Scott Andrew M, Ramsland Paul A
Abstract excerpt
Antibody engineering is important for many diagnostic and clinical applications of monoclonal antibodies. We recently reported a series of fragment crystallizable (Fc) mutations targeting the neonatal Fc receptor (FcRn) site on a Lewis Y (Ley) binding IgG1, hu3S193. The hu3S193 variants displayed shortened in vivo half-lives and may have potential for radioimaging or radiotherapy of Ley-positive tumors. Here, we...
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