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Article

Structure and molecular interactions of a unique antitumor antibody specific for N-glycolyl GM3.

The Journal of biological chemistry - 13 Feb 2004

Krengel Ute, Olsson Lise-Lotte, Martínez Carlos, Talavera Ariel, Rojas Gertrudis, Mier Elin, Angström Jonas, Moreno Ernesto

Abstract excerpt

N-glycolyl GM3 ganglioside is an attractive target antigen for cancer immunotherapy, because this epitope is a molecular marker of certain tumor cells and not expressed in normal human tissues. The murine monoclonal antibody 14F7 specifically recognizes N-glycolyl GM3 and shows no cross-reactivity with the abundant N-acetyl GM3 ganglioside, a close structural homologue of N-glycolyl GM3. Here, we report the...

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PMID: 14627696
DOI: 10.1074/jbc.M311693200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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