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Article

Effective rational humanization of a PASylated anti-galectin-3 Fab for the sensitive PET imaging of thyroid cancer in vivo.

Scientific reports - 1 Apr 2021

Peplau Emanuel, De Rose Francesco, Eichinger Andreas, Reder Sybille, Mittelhäuser Markus, Scafetta Giorgia, Schwaiger Markus, Weber Wolfgang A, Bartolazzi Armando, D'Alessandria Calogero, Skerra Arne

Abstract excerpt

The lack of a non-invasive test for malignant thyroid nodules makes the diagnosis of thyroid cancer (TC) challenging. Human galectin-3 (hGal3) has emerged as a promising target for medical TC imaging and diagnosis because of its exclusive overexpression in malignant thyroid tissues. We previously developed a human-chimeric αhGal3 Fab fragment derived from the rat monoclonal antibody (mAb) M3/38 with optimized...

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Share to Antibodies, Monoclonal, Humanized
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 33795750
DOI: 10.1038/s41598-021-86641-0
PMCID: PMC8016950

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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