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Article

Negative feedback regulation of Wnt signaling by Gbetagamma-mediated reduction of Dishevelled.

Experimental & molecular medicine - 31 Oct 2009

Jung Hwajin, Kim Hyun Joon, Lee Suk Kyung, Kim Rokki, Kopachik Will, Han Jin-Kwan, Jho Eek-hoon

Abstract excerpt

Wnt signaling is known to be important for diverse embryonic and post-natal cellular events and be regulated by the proteins Dishevelled and Axin. Although Dishevelled is activated by Wnt and involved in signal transduction, it is not clear how Dishevelled-mediated signaling is turned off. We report that guanine nucleotide binding protein beta 2 (Gnb2; Gbeta2) bound to Axin and Gbeta2 inhibited Wnt mediated...

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Identifiers

PMID: 19561403
DOI: 10.3858/emm.2009.41.10.076
PMCID: PMC2772972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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