Article
A structural basis for integrin activation by the cytoplasmic tail of the alpha IIb-subunit.
Proceedings of the National Academy of Sciences of the United States of America - 15 Feb 2000
Vinogradova O, Haas T, Plow E F, Qin J
Abstract excerpt
A key step in the activation of heterodimeric integrin adhesion receptors is the transmission of an agonist-induced cellular signal from the short alpha- and/or beta-cytoplasmic tails to the extracellular domains of the receptor. The structural details of how the cytoplasmic tails mediate such an inside-out signaling process remain unclear. We report herein the NMR structures of a membrane-anchored cytoplasmic...
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