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Article

The critical cytoplasmic regions of the alphaL/beta2 integrin in Rap1-induced adhesion and migration.

Molecular biology of the cell - 1 Jun 2003

Tohyama Yumi, Katagiri Koko, Pardi Ruggero, Lu Chafen, Springer Timothy A, Kinashi Tatsuo

Abstract excerpt

Rap1 is a potent inside-out signal that increases LFA-1 adhesive activity. In this study, we have defined the cytoplasmic region of the alphaL and beta2 integrin that are required for Rap1-stimulated adhesion and subsequent migration on ICAM-1. Human LFA-1 bearing truncated and point-mutated alphaL and beta2 cytoplasmic regions were reconstituted in mouse IL-3-dependent proB cells, BAF/3. Truncation of the...

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Share to Cell Adhesion
Share to Cell Movement
Share to Lymphocyte Function-Associated Antigen-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Structure, Tertiary

Share to rap1 GTP-Binding Proteins

Source

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Identifiers

PMID: 12808052
DOI: 10.1091/mbc.e02-09-0615
PMCID: PMC194904

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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