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Article

Basic amino-acid side chains regulate transmembrane integrin signalling.

Nature - 18 Dec 2011

Kim Chungho, Schmidt Thomas, Cho Eun-Gyung, Ye Feng, Ulmer Tobias S, Ginsberg Mark H

Abstract excerpt

Side chains of Lys/Arg near transmembrane domain (TMD) membrane-water interfaces can 'snorkel', placing their positive charge near negatively charged phospholipid head groups; however, snorkelling's functional effects are obscure. Integrin β TMDs have such conserved basic amino acids. Here we use NMR spectroscopy to show that integrin β(3)(Lys 716) helps determine β(3) TMD topography. The α(ΙΙb)β(3) TMD structure...

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Identifiers

PMID: 22178926
DOI: 10.1038/nature10697
PMCID: PMC3257387

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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