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Article

Intercellular adhesion molecule-3 binding of integrin alphaL beta2 requires both extension and opening of the integrin headpiece.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2008

Tang Xiao-Yan, Li Yan-Feng, Tan Suet-Mien

Abstract excerpt

The leukocyte-restricted integrin alpha(L)beta(2) is required in immune processes such as leukocyte adhesion, migration, and immune synapse formation. Activation of alpha(L)beta(2) by conformational changes promotes alpha(L)beta(2) binding to its ligands, ICAMs. It was reported that different affinity states of alpha(L)beta(2) are required for binding ICAM-1 and ICAM-3. Recently, the bent, extended with a closed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18354203
DOI: 10.4049/jimmunol.180.7.4793

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Intercellular adhesion molecule-3 binding of integrin alphaL beta2 requires both extension and opening of the integrin headpiece.PMID 18354203Read ↗

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