Article
Tests of the extension and deadbolt models of integrin activation.
The Journal of biological chemistry - 20 Apr 2007
Zhu Jieqing, Boylan Brian, Luo Bing-Hao, Newman Peter J, Springer Timothy A
Abstract excerpt
Despite extensive evidence that integrin conformational changes between bent and extended conformations regulate affinity for ligands, an alternative hypothesis has been proposed in which a "deadbolt" can regulate affinity for ligand in the absence of extension. Here, we tested both the deadbolt and the extension models. According to the deadbolt model, a hairpin loop in the beta3 tail domain could act as a...
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