Article
Inflammatory pain is enhanced in delta opioid receptor-knockout mice.
The European journal of neuroscience - 1 May 2008
Gavériaux-Ruff Claire, Karchewski Laurie A, Hever Xavier, Matifas Audrey, Kieffer Brigitte L
Abstract excerpt
To examine the involvement of opioid receptors in inflammatory pain, we compared Complete Freund's Adjuvant-induced hyperalgesia in mice lacking mu, delta or kappa receptors under the same experimental conditions. Mechanical allodynia and thermal hyperalgesia were measured using von Frey filaments and the plantar test, respectively. All three receptor-knockout mice, as well as wild-type animals, developed...
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