Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The p16INK4alpha/p19ARF gene mutations are infrequent and are mutually exclusive to p53 mutations in Indian oral squamous cell carcinomas.

International journal of oncology - 1 Mar 2000

Kannan K, Munirajan A K, Krishnamurthy J, Bhuvarahamurthy V, Mohanprasad B K, Panishankar K H, Tsuchida N, Shanmugam G

Abstract excerpt

Eighty-seven untreated primary oral squamous cell carcinomas (SCCs) associated with betel quid and tobacco chewing from Indian patients were analysed for the presence of mutations in the commonly shared exon 2 of p16INK4alpha/p19ARF genes. Polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) and sequencing analysis were used to detect mutations. SSCP analysis indicated that only 9% (8/87)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Squamous Cell

Share to Genes, p16

Share to Genes, p53

Share to Mouth Neoplasms

Share to Proteins

Share to Tumor Suppressor Protein p14ARF

Source

Identifiers

PMID: 10675493
DOI: 10.3892/ijo.16.3.585

Genes

CGA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The p16INK4alpha/p19ARF gene mutations are infrequent and are mutually exclusive to p53 mutations in Indian oral squamous cell carcinomas.PMID 10675493Read ↗

Mutation profile of the p53, fhit, p16INK4a/p19ARF and H-ras genes in Indian breast carcinomas.Semantic proximity Read ↗

Low incidence of p53 mutations in betel quid and tobacco chewing-associated oral squamous carcinoma from India.Semantic proximity Read ↗

p53 inactivation in chewing tobacco-induced oral cancers and leukoplakias from India.Semantic proximity Read ↗

Inactivation of the p14ARF, p15INK4B and p16INK4A genes is a frequent event in human oral squamous cell carcinomasSemantic proximity Read ↗

Mutations of the INK4a locus in squamous cell carcinomas of human skin.Semantic proximity Read ↗

Mutations and polymorphisms in the p53, p21 and p16 genes in oral carcinomas of Indian betel quid chewers.Semantic proximity Read ↗

"p53 mutation spectrum and its role in prognosis of oral cancer patients: A study from Gujarat, West India".Semantic proximity Read ↗

Alterations of the p14ARF-p53-MDM2 pathway in oral squamous cell carcinoma: MDM2 overexpression is a common event.Semantic proximity Read ↗

Somatic INK4a-ARF locus mutations: a significant mechanism of gene inactivation in squamous cell carcinomas of the head and neck.Semantic proximity Read ↗

Mutations of the cell cycle regulatory genes p16INK4A and p21WAF1 and the metastasis-inducing gene S100A4 are infrequent and unrelated to p53 tumour suppressor gene status and data on survival in oropharyngeal squamous cell carcinomas.Semantic proximity Read ↗

Characteristics of mutations in the p53 gene of oral squamous-cell carcinomas associated with betel-quid chewing in Sri Lanka.Semantic proximity Read ↗

Expression of p16INK4A, p53, and Rb proteins are independent from the presence of human papillomavirus genes in oral squamous cell carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.