Mutations of the INK4a locus in squamous cell carcinomas of human skin.

doi:10.1006/bbrc.1997.6217

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Article

Mutations of the INK4a locus in squamous cell carcinomas of human skin.

Biochemical and biophysical research communications - 6 Mar 1997

Kubo Y, Urano Y, Matsumoto K, Ahsan K, Arase S

Abstract excerpt

The INK4a locus encodes two different, cell cycle-regulating proteins, p16INK4a and p19ARF. In this study, we screened mutations in all coding regions of the INK4a locus (exons 1 beta, 1 alpha, 2, and 3) in 21 squamous cell carcinomas (SCCs) of human skin by polymerase chain reaction-single stran...

Topics

Carcinoma, Squamous Cell
Carrier Proteins
Cyclin-Dependent Kinase Inhibitor p16
Humans
Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Proteins
Skin Neoplasms
Tumor Suppressor Protein p14ARF

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