Article
Kinase-dependent change in the conformation of the leukocyte NADPH oxidase subunit p47phox.
Molecules and cells - 31 Dec 1999
Park J W, Park H S, Chang Y M
Abstract excerpt
The leukocyte NADPH oxidase of neutrophils is a membrane-bound enzyme that catalyzes the production of O2- from oxygen using NADPH as the electron donor. Dormant in resting neutrophils, the enzyme acquires catalytic activity when the cells are exposed to appropriate stimuli. During activation, the cytosolic oxidase components p47phox and p67phox migrate to the plasma membrane, where they associate with cytochrome...
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