Activation of p47(PHOX), a cytosolic subunit of the leukocyte NADPH oxidase. Phosphorylation of ser-359 or ser-370 precedes phosphorylation at other sites and is required for activity.

doi:10.1074/jbc.273.52.35147

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Article

Activation of p47(PHOX), a cytosolic subunit of the leukocyte NADPH oxidase. Phosphorylation of ser-359 or ser-370 precedes phosphorylation at other sites and is required for activity.

The Journal of biological chemistry - 25 Dec 1998

Johnson J L, Park J W, Benna J E, Faust L P, Inanami O, Babior B M

Abstract excerpt

The leukocyte NADPH oxidase catalyzes the reduction of oxygen to superoxide (O-2) at the expense of NADPH in phagocytes and B lymphocytes. The enzyme is dormant in resting cells but becomes active when the cells are exposed to appropriate stimuli. During oxidase activation, the highly basic cytos...

Topics

Arachidonic Acid
Biological Transport
Cytosol
Enzyme Activation
Hematopoietic Stem Cells
Leukocytes
Lymphocytes
Mutation
NADPH Oxidases
Phosphoproteins
Phosphorylation
Recombinant Proteins
Serine

Source

Open in PubMed

Identifiers

PMID: 9857051
DOI: 10.1074/jbc.273.52.35147

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9857051-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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