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Article

Phosphorylation of p22phox on threonine 147 enhances NADPH oxidase activity by promoting p47phox binding.

The Journal of biological chemistry - 29 Jan 2010

Lewis Eric M, Sergeant Susan, Ledford Bill, Stull Natalie, Dinauer Mary C, McPhail Linda C

Abstract excerpt

NADPH oxidase comprises both cytosolic and membrane-bound subunits, which, when assembled and activated, initiate the transfer of electrons from NADPH to molecular oxygen to form superoxide. This activity, known as the respiratory burst, is extremely important in the innate immune response as indicated by the disorder chronic granulomatous disease. The regulation of this enzyme complex involves protein-protein...

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Identifiers

PMID: 19948736
DOI: 10.1074/jbc.M109.030643
PMCID: PMC2823407

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phosphorylation of p22phox on threonine 147 enhances NADPH oxidase activity by promoting p47phox binding.PMID 19948736Read ↗

Activation of p47(PHOX), a cytosolic subunit of the leukocyte NADPH oxidase. Phosphorylation of ser-359 or ser-370 precedes phosphorylation at other sites and is required for activity.Semantic proximity Read ↗

Activation of the phagocyte NADPH oxidase protein p47(phox). Phosphorylation controls SH3 domain-dependent binding to p22(phox).Semantic proximity Read ↗

NOX Activation by Subunit Interaction and Underlying Mechanisms in DiseaseSemantic proximity Read ↗

Characterization of a mutation in the Phox homology domain of the NADPH oxidase component p40phox identifies a mechanism for negative regulation of superoxide production.Semantic proximity Read ↗

p40phox as an alternative organizer to p47phox in Nox2 activation: a new mechanism involving an interaction with p22phox.Semantic proximity Read ↗

Arachidonic acid induces direct interaction of the p67(phox)-Rac complex with the phagocyte oxidase Nox2, leading to superoxide production.Semantic proximity Read ↗

Cooperation of p40(phox) with p47(phox) for Nox2-based NADPH oxidase activation during Fcγ receptor (FcγR)-mediated phagocytosis: mechanism for acquisition of p40(phox) phosphatidylinositol 3-phosphate (PI(3)P) binding.Semantic proximity Read ↗

Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism.Semantic proximity Read ↗

Mutations in the PX-SH3A linker of p47phox decouple PI(3,4)P2 binding from NADPH oxidase activation.Semantic proximity Read ↗

A regulated adaptor function of p40phox: distinct p67phox membrane targeting by p40phox and by p47phox.Semantic proximity Read ↗

Role for the first SH3 domain of p67phox in activation of superoxide-producing NADPH oxidases.Semantic proximity Read ↗

Crucial role of two potential cytosolic regions of Nox2, 191TSSTKTIRRS200 and 484DESQANHFAVHHDEEKD500, on NADPH oxidase activation.Semantic proximity Read ↗

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