Article
Relationship between haloperidol plasma concentration, debrisoquine metabolic ratio, CYP2D6 and CYP2C9 genotypes in psychiatric patients.
Pharmacopsychiatry - 1 Mar 2004
LLerena Adrián, de la Rubia Alfredo, Berecz Roland, Dorado Pedro
Abstract excerpt
BACKGROUND: Around seven percent of Caucasians are poor metabolizers of cytochrome P450, CYP2D6 due to genetically impaired activity of the enzyme. Haloperidol in vitro and in vivo inhibits the activity of CYP2D6 and also the involvement of the enzyme in haloperidol metabolism has been reported. The present study was aimed to evaluate the possible inhibition of CYP2D6 during haloperidol treatment, and to...
Topics
- Adult
- Aged
- Aryl Hydrocarbon Hydroxylases
- Chromatography, High Pressure Liquid
- Cytochrome P-450 CYP2C9
- Cytochrome P-450 CYP2D6
- Debrisoquin
- Female
- Genotype
- Haloperidol
- Humans
- Male
- Mental Disorders
- Middle Aged
- RNA, Messenger