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Article

Analysis of the adenomatous polyposis coli (APC) gene in childhood and adolescent germ cell tumors.

Pediatric blood & cancer - 1 Mar 2011

Okpanyi Vera, Schneider Dominik T, Zahn Susanne, Sievers Sonja, Calaminus Gabriele, Nicholson James C, Palmer Roger D, Leuschner Ivo, Borkhardt Arndt, Schönberger Stefan

Abstract excerpt

BACKGROUND: Aberrant Wnt signaling due to deregulation of Wnt regulators is implicated in the development and progression of numerous embryonal tumors. This study addresses the questions if activation of Wnt signaling in germ cell tumors (GCTs) arising during childhood and adolescence is associated with aberrations of the tumor suppressor adenomatous polyposis coli (APC), and whether APC aberrations might be...

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Share to Adenomatous Polyposis Coli Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenomics

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Share to Loss of Heterozygosity

Share to Neoplasms, Germ Cell and Embryonal

Share to Reverse Transcriptase Polymerase Chain Reaction

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Source

Identifiers

PMID: 21225915
DOI: 10.1002/pbc.22669

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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