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Article

K-ras2 activation and genome instability increase proliferation and size of FAP adenomas.

Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology - 1 Jan 1999

Rapallo A, Sciutto A, Geido E, Orecchia R, Infusini E, Pujic N, d'Amore E S, Monaco R, Risio M, Rossini F P, Giaretti W

Abstract excerpt

The possible role of K-ras2 mutations and aneuploidy toward increase of proliferation and adenoma size in Familial Adenomatous Polyposis (FAP) adenomas is not known. The present study addresses these issues by investigating 147 colorectal adenomas obtained from four FAP patients. The majority of adenomas had size lower than or equal to 10 mm (86%), low grade dysplasia (63%), and were preferentially located in the...

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Source

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Identifiers

PMID: 10661623
DOI: 10.1155/1999/257265
PMCID: PMC4615181

Genes

FAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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