Article
[K-ras gene mutations in adenomas from familial adenomatous polyposis].
Gan to kagaku ryoho. Cancer & chemotherapy - 1 Jun 1996
Ohki S, Onda M, Nomizu T, Tsuchiya A, Ami H, Fukushima T, Takita K, Kanazawa M, Watanabe F, Andoh Y, Yoshida T, Abe R
Abstract excerpt
A 18-year-old woman underwent total colectomy for familial adenomatous polyposis. In order to clarify the significance of K-ras mutations in early colorectal carcinogenesis, K-ras mutations were analyzed in multiple adenomas by PCR-SSCP method. A total of 256 adenomas were found throughout the entire colon and rectum, and the distribution was a sparse type. The correlation between K-ras gene and...
Topics
- Adenoma
- Adenomatous Polyposis Coli
- Colonic Polyps
- Female
- Genes, APC
- Genes, ras
- Humans
- Male
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational