Article
Characterization of an allelic variant in the nifedipine-specific element of CYP3A4: ethnic distribution and implications for prostate cancer risk. Mutations in brief no. 191. Online.
Human mutation - 1 Jan 1998
Walker A H, Jaffe J M, Gunasegaram S, Cummings S A, Huang C S, Chern H D, Olopade O I, Weber B L, Rebbeck T R
Abstract excerpt
CYP3A4 is involved in the metabolism of numerous biologically active compounds, including testosterone. A genetic variant located in the P450NF (nifedipine) specific element (NFSE) has been identified that disrupts a transciptional regulatory element located in the 5' regulatory region of CYP3A4. The CYP3A4 variant (CYP3A4-V) is associated with the clinical presentation of prostate cancer. There are significant...
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