Article
Association between a CYP3A4 genetic variant and clinical presentation in African-American prostate cancer patients.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 1999
Paris P L, Kupelian P A, Hall J M, Williams T L, Levin H, Klein E A, Casey G, Witte J S
Abstract excerpt
Prostate cancer incidence, clinical presentation, and mortality rates vary among different ethnic groups. A genetic variant of CYP3A4, a gene involved in the oxidative deactivation of testosterone, has been associated recently with prostate cancer development in Caucasians. To further investigate this variant, we evaluated its genotype frequencies in different ethnic groups and its association with clinical...
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