Article
Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4.
Journal of the National Cancer Institute - 19 Aug 1998
Rebbeck T R, Jaffe J M, Walker A H, Wein A J, Malkowicz S B
Abstract excerpt
BACKGROUND: Pathways involved in androgen metabolism have been implicated in the etiology of prostate cancer. The goal of this study was to evaluate the effect of CYP3A4, a gene associated with the oxidative deactivation of testosterone, on the clinical presentation of prostate cancers. METHODS:...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System
- Diagnosis, Differential
- Disease Susceptibility
- Genetic Variation
- Genotype
- Germ-Line Mutation
- Humans
- Male
- Middle Aged
- Mixed Function Oxygenases
- Neoplasm Staging
- Prostatic Neoplasms