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Article

Detection of MboII Polymorphism at the 5′ Promoter Region of CYP3A4

1 Feb 2001

Abstract excerpt

The P450 cytochromes are a superfamily of hemeproteins that catalyze the metabolism of a large number of xenobiotics and endobiotics. CYP3A4 is the major form of P450 in human liver, metabolizing >50% of all drugs (1). Differences in drug metabolism rates can lead to severe toxicity or therapeutic failure by altering the relationship between dose and blood concentration of the pharmacologically active drug (2)....

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PMID: 11159790
DOI: 10.1093/clinchem/47.2.348

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