Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Coordinate modulation of Sp1, NF‐kappa B, and p53 in confluent human malignant melanoma cells after ionizing radiation

1 Feb 2000

Abstract excerpt

Regulation of transcriptional responses in growth-arrested human cells under conditions that promote potentially lethal damage repair after ionizing radiation (IR) is poorly understood. Sp1/retinoblastoma control protein (RCP) DNA binding increased within 30 min and peaked at 2-4 h after IR (450-600 cGy) in confluent radioresistant human malignant melanoma (U1-Mel) cells. Increased phosphorylation of Sp1 directly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to NF-κB Signaling Pathways
Share to Ocular Oncology and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10657994
DOI: 10.1096/fasebj.14.2.379

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Coordinate modulation of Sp1, NF‐kappa B, and p53 in confluent human malignant melanoma cells after ionizing radiationPMID 10657994Read ↗

Functional analysis of the p53 pathway in response to ionizing radiation in uveal melanoma.Semantic proximity Read ↗

Diminished capacity for p53 in mediating a radiation-induced G1 arrest in established human tumor cell lines.Semantic proximity Read ↗

Radiation-stimulated ERK1/2 and JNK1/2 signaling can promote cell cycle progression in human colon cancer cells.Semantic proximity Read ↗

EGR-1 induction is required for maximal radiosensitivity in A375-C6 melanoma cells.Semantic proximity Read ↗

An abnormality in the p53 pathway following gamma-irradiation in many wild-type p53 human melanoma lines.Semantic proximity Read ↗

Induction of p53-dependent Activation of the Human Proliferating Cell Nuclear Antigen Gene in Chromatin by Ionizing RadiationSemantic proximity Read ↗

p53 modulates radiation sensitivity independent of p21 transcriptional activation.Semantic proximity Read ↗

p53 gene mutations and abnormal retinoblastoma protein in radiation-induced human sarcomas.Semantic proximity Read ↗

Sp1-p53 heterocomplex mediates activation of HTLV-I long terminal repeat by 12-O-tetradecanoylphorbol-13-acetate that is antagonized by protein kinase C.Semantic proximity Read ↗

Mutant human tumor suppressor p53 modulates the activation of mitogen-activated protein kinase and nuclear factor-kappaB, but not c-Jun N-terminal kinase and activated protein-1.Semantic proximity Read ↗

c-jun and Egr-1 Participate in DNA Synthesis and Cell Survival in Response to Ionizing Radiation ExposureSemantic proximity Read ↗

Molecular events in radiation transformation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.