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Article

EGR-1 induction is required for maximal radiosensitivity in A375-C6 melanoma cells.

The Journal of biological chemistry - 15 Nov 1996

Ahmed M M, Venkatasubbarao K, Fruitwala S M, Muthukkumar S, Wood D P, Sells S F, Mohiuddin M, Rangnekar V M

Abstract excerpt

Exposure to ionizing radiation leads to induction of the immediate-early gene, early growth response-1 (Egr-1). Previous studies have suggested distinct cell type- and inducer-specific roles for EGR-1 protein in cellular growth inhibition. The present study was undertaken to determine the functio...

Topics

Cell Division
DNA-Binding Proteins
Early Growth Response Protein 1
Genes, Dominant
Humans
Immediate-Early Proteins
Melanoma
Mutation
Oligonucleotides, Antisense
Phenotype
Radiation Tolerance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcription Factors

Transfection

Tumor Cells, Cultured

Tumor Suppressor Protein p53

Zinc Fingers

Source

Identifiers

PMID: 8910582
DOI: 10.1074/jbc.271.46.29231

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8910582-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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