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Article

EGR-1 induction is required for maximal radiosensitivity in A375-C6 melanoma cells.

The Journal of biological chemistry - 15 Nov 1996

Ahmed M M, Venkatasubbarao K, Fruitwala S M, Muthukkumar S, Wood D P, Sells S F, Mohiuddin M, Rangnekar V M

Abstract excerpt

Exposure to ionizing radiation leads to induction of the immediate-early gene, early growth response-1 (Egr-1). Previous studies have suggested distinct cell type- and inducer-specific roles for EGR-1 protein in cellular growth inhibition. The present study was undertaken to determine the functional role of EGR-1 in growth inhibition caused by exposure of tumor cells to ionizing radiation. Exposure to ionizing...

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Identifiers

PMID: 8910582
DOI: 10.1074/jbc.271.46.29231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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