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Article

Functional analysis of the p53 pathway in response to ionizing radiation in uveal melanoma.

Investigative ophthalmology & visual science - 1 May 2005

Sun Young, Tran Binh N, Worley Lori A, Delston Rachel B, Harbour J William

Abstract excerpt

PURPOSE: Uveal melanomas are notoriously radioresistant and thus necessitate treatment with extremely high radiation doses that often cause ocular complications. The p53 tumor suppressor pathway is a major mediator of the cellular response to radiation-induced DNA damage, suggesting that this pathway may be defective in uveal melanoma. The current study was conducted to analyze the functional integrity of the p53...

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Source

Identifiers

PMID: 15851551
DOI: 10.1167/iovs.04-1362

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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