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Article

p53 modulates radiation sensitivity independent of p21 transcriptional activation.

American journal of clinical oncology - 1 Feb 2005

Mazzatti Dawn J, Lee Yi-Jang, Helt Christopher E, O'Reilly Michael A, Keng Peter C

Abstract excerpt

Cellular sensitivity to ionizing radiation (IR) treatment is a complex biologic phenomenon that is affected by several processes, namely the ability of the cell to detect and repair DNA damage, regulate cell cycle division, and execute apoptosis. Because the p53 tumor suppressor protein is implicated in the regulation of each of these processes, radiation sensitivity of H1299 p53-null human lung carcinoma cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15685034
DOI: 10.1097/01.coc.0000139484.51715.5a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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