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Article

Inhibin α-subunit N terminus interacts with activin type IB receptor to disrupt activin signaling.

The Journal of biological chemistry - 9 Mar 2012

Zhu Jie, Lin S Jack, Zou Chao, Makanji Yogeshwar, Jardetzky Theodore S, Woodruff Teresa K

Abstract excerpt

Inhibin is a heterodimeric peptide hormone produced in the ovary that antagonizes activin signaling and FSH synthesis in the pituitary. The inhibin β-subunit interacts with the activin type II receptor (ActRII) to functionally antagonize activin. The inhibin α-subunit mature domain (N terminus) arose relatively early during the evolution of the hormone, and inhibin function is decreased by an antibody directed...

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Identifiers

PMID: 22267736
DOI: 10.1074/jbc.M111.293381
PMCID: PMC3318740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inhibin α-subunit N terminus interacts with activin type IB receptor to disrupt activin signaling.PMID 22267736Read ↗

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Inhibin-A Antagonizes TGFβ2 Signaling by Down-Regulating Cell Surface Expression of the TGFβ Coreceptor BetaglycanSemantic proximity Read ↗

Endogenous Betaglycan Is Essential for High-Potency Inhibin Antagonism in GonadotropesSemantic proximity Read ↗

Functional analysis of the human inhibin alpha subunit variant A257T and its potential role in premature ovarian failure.Semantic proximity Read ↗

Identification of distinct inhibin and transforming growth factor beta-binding sites on betaglycan: functional separation of betaglycan co-receptor actions.Semantic proximity Read ↗

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Inhibin B is a more potent suppressor of rat follicle-stimulating hormone release than inhibin a in vitro and in vivo.Semantic proximity Read ↗

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