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Article

timrit Lengthens circadian period in a temperature-dependent manner through suppression of PERIOD protein cycling and nuclear localization.

Molecular and cellular biology - 1 Jun 1999

Matsumoto A, Tomioka K, Chiba Y, Tanimura T

Abstract excerpt

A fundamental feature of circadian clocks is temperature compensation of period. The free-running period of ritsu (timrit) (a novel allele of timeless [tim]) mutants is drastically lengthened in a temperature-dependent manner. PER and TIM protein levels become lower in timrit mutants as temperature becomes higher. This mutation reduces per mRNA but not tim mRNA abundance. PER constitutively driven by the...

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Identifiers

PMID: 10330175
DOI: 10.1128/MCB.19.6.4343
PMCID: PMC104394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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timrit Lengthens circadian period in a temperature-dependent manner through suppression of PERIOD protein cycling and nuclear localization.PMID 10330175Read ↗

Altered entrainment and feedback loop function effected by a mutant period protein.Semantic proximity Read ↗

The timSL mutant affects a restricted portion of the Drosophila melanogaster circadian cycle.Semantic proximity Read ↗

Post-translational regulation and nuclear entry of TIMELESS and PERIOD are affected in new timeless mutant.Semantic proximity Read ↗

Suppression of PERIOD protein abundance and circadian cycling by the Drosophila clock mutation timeless.Semantic proximity Read ↗

A TIMELESS-independent function for PERIOD proteins in the Drosophila clock.Semantic proximity Read ↗

Rhythmic expression of timeless: a basis for promoting circadian cycles in period gene autoregulation.Semantic proximity Read ↗

The timSL mutant of the Drosophila rhythm gene timeless manifests allele-specific interactions with period gene mutants.Semantic proximity Read ↗

Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock.Semantic proximity Read ↗

TIMELESS is an important mediator of CK2 effects on circadian clock function in vivo.Semantic proximity Read ↗

The Drosophila double-timeS mutation delays the nuclear accumulation of period protein and affects the feedback regulation of period mRNA.Semantic proximity Read ↗

Molecular and behavioral analysis of four period mutants in Drosophila melanogaster encompassing extreme short, novel long, and unorthodox arrhythmic types.Semantic proximity Read ↗

double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation.Semantic proximity Read ↗

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