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Article

Sequence diversity of the merozoite surface protein 1 of Plasmodium falciparum in clinical isolates from the Kilombero District, Tanzania.

Acta tropica - 5 Jan 2000

Jiang G, Daubenberger C, Huber W, Matile H, Tanner M, Pluschke G

Abstract excerpt

Merozoite surface protein 1 of Plasmodium falciparum (PfMSP-1) is regarded as a key candidate antigen for malaria vaccine development. It exhibits significant antigenic polymorphism and has been divided into 17 building blocks based on the analysis of sequence diversity. Differences in the antigenic composition of PfMSP-1 in local P. falciparum populations may result in differences in the efficacy of vaccines,...

Topics

Amino Acid Sequence
Animals
DNA, Protozoan
Genetic Variation
Humans
Merozoite Surface Protein 1
Molecular Sequence Data
Plasmodium falciparum
Polymerase Chain Reaction
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Sequence Analysis, Protein

Tanzania

Source

Identifiers

PMID: 10643908
DOI: 10.1016/s0001-706x(99)00045-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-10643908-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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