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Article

Sequence diversity of the merozoite surface protein 1 of Plasmodium falciparum in clinical isolates from the Kilombero District, Tanzania.

Acta tropica - 5 Jan 2000

Jiang G, Daubenberger C, Huber W, Matile H, Tanner M, Pluschke G

Abstract excerpt

Merozoite surface protein 1 of Plasmodium falciparum (PfMSP-1) is regarded as a key candidate antigen for malaria vaccine development. It exhibits significant antigenic polymorphism and has been divided into 17 building blocks based on the analysis of sequence diversity. Differences in the antigenic composition of PfMSP-1 in local P. falciparum populations may result in differences in the efficacy of vaccines,...

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PMID: 10643908
DOI: 10.1016/s0001-706x(99)00045-5

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