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Article

Genetic diversity of MSP1 Block 2 of Plasmodium vivax isolates from Manaus (central Brazilian Amazon).

Journal of immunology research - 1 Jan 2014

Soares Leidiane Amorim, Evangelista Janaína, Orlandi Patricia Puccinelli, Almeida Maria Edilene, de Sousa Luciana Pereira, Chaves Yury, Barbosa-Filho Roberto, Lacerda Marcus Vinícius, Mariuba Luis André, Nogueira Paulo Afonso

Abstract excerpt

The diversity of MSP1 in both Plasmodium falciparum and P. vivax is presumed be associated to parasite immune evasion. In this study, we assessed genetic diversity of the most variable domain of vaccine candidate N-terminal PvMSP1 (Block 2) in field isolates of Manaus. Forty-seven blood samples the polymorphism of PvMSP1 Block 2 generates four fragment sizes. In twenty-eight of them, sequencing indicated seven...

Topics

Amino Acid Sequence
Antigens, Protozoan
Brazil
Epitopes, B-Lymphocyte
Haplotypes
Humans
Immune Evasion
Malaria, Vivax
Merozoite Surface Protein 1
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmodium vivax

Polymorphism, Single Nucleotide

Sequence Alignment

Source

Open in PubMed Open full text

Identifiers

PMID: 24741614
DOI: 10.1155/2014/671050
PMCID: PMC3987980

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-24741614-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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