Article
Analysis of sequence diversity in the Plasmodium falciparum merozoite surface protein-1 (MSP-1).
Molecular and biochemical parasitology - 1 May 1993
Miller L H, Roberts T, Shahabuddin M, McCutchan T F
Abstract excerpt
Immunization with the first identified Plasmodium falciparum merozoite surface protein (MSP-1) protected monkeys from an otherwise fatal infection. The question of whether the high degree of diversity in MSP-1 among parasite clones will be an impediment to its development as a vaccine candidate needs to be resolved. We have aligned all published sequences, identifying errors, resequencing a portion of one...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Antigenic Variation
- Antigens, Protozoan
- Antigens, Surface
- Merozoite Surface Protein 1
- Models, Genetic
- Molecular Sequence Data
- Plasmodium falciparum
- Protein Precursors