Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antisense oligonucleotides targeted to the p53 gene modulate liver regeneration in vivo.

Drug metabolism and disposition: the biological fate of chemicals - 1 Feb 2000

Arora V, Iversen P L

Abstract excerpt

The rapidly proliferating cells of the regenerating liver after partial hepatectomy (PH) present a reproducible in vivo model to study the functional role of the tumor suppressor gene p53. The present study uses the rat 70% PH model along with systemic administration of three different structural types of antisense oligonucleotides (ODNs) designed to suppress p53 expression. We tested the hypothesis that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatectomy
Share to Liver Regeneration
Share to Microsomes, Liver

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mitotic Index

Share to NADH, NADPH Oxidoreductases

Share to Oligonucleotides, Antisense

Share to Proliferating Cell Nuclear Antigen

Share to Thiobarbituric Acid Reactive Substances

Source

Identifiers

PMID: 10640509

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antisense oligonucleotides targeted to the p53 gene modulate liver regeneration in vivo.PMID 10640509Read ↗

Liver regeneration and alpha-fetoprotein messenger RNA expression in the retrorsine model for hepatocyte transplantation.Semantic proximity Read ↗

Temporal expression profiles indicate a primary function for microRNA during the peak of DNA replication after rat partial hepatectomySemantic proximity Read ↗

Control of mouse hepatocyte proliferation and ploidy by p53 and p53ser246 mutation in vivo.Semantic proximity Read ↗

Massive repopulation of rat liver by transplantation of hepatocytes into specific lobes of the liver and ligation of portal vein branches to other lobes.Semantic proximity Read ↗

Mutation and expression of the p53 gene during chemical hepatocarcinogenesis in F344 rats.Semantic proximity Read ↗

Ha-ras mutations in N-nitrosomorpholine-induced lesions and inhibition of hepatocarcinogenesis by antisense sequences in rat liver.Semantic proximity Read ↗

Cell proliferation in liver of Mmh/Ogg1-deficient mice enhances mutation frequency because of the presence of 8-hydroxyguanine in DNA.Semantic proximity Read ↗

Variation in expression of genes used for normalization of Northern blots after induction of cell proliferation.Semantic proximity Read ↗

Antisense oligonucleotides directed against p53 have antiproliferative effects unrelated to effects on p53 expression.Semantic proximity Read ↗

Effects of deletion variant of hepatocyte growth factor on reduced-size liver transplantation in rats.Semantic proximity Read ↗

Cell proliferation and advancement of hepatocarcinogenesis in the rat are associated with a decrease in connexin 32 expression.Semantic proximity Read ↗

Inhibition of repair of O6-methyldeoxyguanosine and enhanced mutagenesis in rat-liver epithelial cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.