Article
Antisense oligonucleotides directed against p53 have antiproliferative effects unrelated to effects on p53 expression.
British journal of cancer - 1 Mar 1995
Barton C M, Lemoine N R
Abstract excerpt
Antisense oligonucleotides targeting p53 have been hailed as a potentially new technique for treating patients with cancer, and there have been encouraging reports of good patient tolerance in vivo and of antiproliferative effects in vitro. However, evidence is lacking that these oligonucleotides are acting via an antisense interaction to modulate p53 expression. We examined a phosphorothioate antisense...
Topics
- Base Sequence
- Cell Division
- Codon
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Oligonucleotides, Antisense
- Pancreatic Neoplasms
- Protein Biosynthesis