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Normal Fertilization Occurs with Eggs Lacking the Integrin α6β1 and Is Cd9-Dependent

12 Jun 2000

Abstract excerpt

Previous results, based on inhibition of fertilization by an anti-alpha6 integrin mAb (GoH3), suggest that the alpha6beta1 integrin on mouse eggs functions as the receptor for sperm (Almeida, E.A., A.P. Huovila, A.E. Sutherland, L.E. Stephens, P.G. Calarco, L. M. Shaw, A.M. Mercurio, A. Sonnenberg, P. Primakoff, D.G. Myles, and J.M. White. 1995. Cell. 81:1095-1104). Because the egg surface tetraspanin CD9 is...

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PMID: 10851025
DOI: 10.1083/jcb.149.6.1289

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Normal Fertilization Occurs with Eggs Lacking the Integrin α6β1 and Is Cd9-DependentPMID 10851025Read ↗

Requirement of CD9 on the Egg Plasma Membrane for FertilizationSemantic proximity Read ↗

CD9 controls the formation of clusters that contain tetraspanins and the integrin α6β1, which are involved in human and mouse gamete fusionSemantic proximity Read ↗

Sperm-Egg InteractionSemantic proximity Read ↗

Reduction of Mouse Egg Surface Integrin Alpha9 Subunit (ITGA9) Reduces the Egg's Ability to Support Sperm-Egg Binding and Fusion1Semantic proximity Read ↗

The gamete fusion process is defective in eggs of Cd9-deficient miceSemantic proximity Read ↗

Fertilin β and other ADAMs as integrin ligands: insights into cell adhesion and fertilizationSemantic proximity Read ↗

Possible involvement of CD81 in acrosome reaction of sperm in miceSemantic proximity Read ↗

Residues SFQ (173-175) in the large extracellular loop of CD9 are required for gamete fusionSemantic proximity Read ↗

The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in miceSemantic proximity Read ↗

Transfer of oocyte membrane fragments to fertilizing spermatozoaSemantic proximity Read ↗

Infertility of CD9-deficient mouse eggs is reversed by mouse CD9, human CD9, or mouse CD81; polyadenylated mRNA injection developed for molecular analysis of sperm-egg fusion.Semantic proximity Read ↗

Alpha6beta1 integrin expressed by sperm is determinant in mouse fertilizationSemantic proximity Read ↗

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