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Article

Possible involvement of CD81 in acrosome reaction of sperm in mice

8 Feb 2007

Abstract excerpt

Tetraspanin CD81 is closely homologous in amino acid sequence with CD9. CD9 is well known to be involved in sperm-egg fusion, and CD81 has also been reported to be involved in membrane fusion events. However, the function of CD81 as well as that of CD9 in membrane fusion remains unclear. Here, we report that disruption of the mouse CD81 gene led to a reduction in the fecundity of female mice, and CD81-/- eggs had...

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Identifiers

PMID: 17290409
DOI: 10.1002/mrd.20709

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Related research

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Research trail→

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Possible involvement of CD81 in acrosome reaction of sperm in micePMID 17290409Read ↗

CD81 and CD9 work independently as extracellular components upon fusion of sperm and oocyteSemantic proximity Read ↗

Infertility of CD9-deficient mouse eggs is reversed by mouse CD9, human CD9, or mouse CD81; polyadenylated mRNA injection developed for molecular analysis of sperm-egg fusion.Semantic proximity Read ↗

The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in miceSemantic proximity Read ↗

Transfer of oocyte membrane fragments to fertilizing spermatozoaSemantic proximity Read ↗

Residues SFQ (173-175) in the large extracellular loop of CD9 are required for gamete fusionSemantic proximity Read ↗

Sperm-Egg InteractionSemantic proximity Read ↗

Sperm–egg adhesion and fusion in mammalsSemantic proximity Read ↗

Requirement of CD9 on the Egg Plasma Membrane for FertilizationSemantic proximity Read ↗

CD9 controls the formation of clusters that contain tetraspanins and the integrin α6β1, which are involved in human and mouse gamete fusionSemantic proximity Read ↗

Sperm-Egg Fusion: A Molecular Enigma of Mammalian ReproductionSemantic proximity Read ↗

The gamete fusion process is defective in eggs of Cd9-deficient miceSemantic proximity Read ↗

Binding of sperm protein Izumo1 and its egg receptor Juno drives Cd9 accumulation in the intercellular contact area prior to fusion during mammalian fertilizationSemantic proximity Read ↗

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