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Article

Determinants of syncytium formation in microglia by human immunodeficiency virus type 1: role of the V1/V2 domains.

Journal of virology - 1 Jan 2000

Shieh J T, Martín J, Baltuch G, Malim M H, González-Scarano F

Abstract excerpt

Microglia are the main reservoir for human immunodeficiency virus type 1 (HIV-1) in the central nervous system (CNS), and multinucleated giant cells, the result of fusion of HIV-1-infected microglia and brain macrophages, are the neuropathologic hallmark of HIV dementia. One potential explanation for the formation of syncytia is viral adaptation for these CD4(+) CNS cells. HIV-1(BORI-15), a virus adapted to...

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Share to CD4 Antigens
Share to Cell Fusion
Share to Cell Line, Transformed

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Products, env

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Share to Leukocytes, Mononuclear

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Share to Receptors, CCR5

Source

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Identifiers

PMID: 10623731
DOI: 10.1128/jvi.74.2.693-701.2000
PMCID: PMC111589

Genes

CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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