Functional role of the V1/V2 region of human immunodeficiency virus type 1 envelope glycoprotein gp120 in infection of primary macrophages and soluble CD4 neutralization.

doi:10.1128/JVI.68.4.2253-2259.1994

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Article

Functional role of the V1/V2 region of human immunodeficiency virus type 1 envelope glycoprotein gp120 in infection of primary macrophages and soluble CD4 neutralization.

Journal of virology - 1 Apr 1994

Koito A, Harrowe G, Levy J A, Cheng-Mayer C

Abstract excerpt

We have examined the influence of the V1/V2 region of the human immunodeficiency virus type 1 (HIV-1) gp120 on certain biologic properties of the virus. We observed that on the genomic background of the T-cell-line-tropic strain, HIV-1SF2mc, both the V1 and V2 domains of the macrophage-tropic str...

Topics

Amino Acid Sequence
Animals
CD4 Antigens
Gene Products, env
Glycosylation
HIV Envelope Protein gp120
HIV Envelope Protein gp160
HIV-1
Haplorhini
Humans
Macrophages
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Neutralization Tests

Protein Precursors

Protein Processing, Post-Translational

Recombination, Genetic

Sequence Homology, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 8139010
DOI: 10.1128/JVI.68.4.2253-2259.1994
PMCID: PMC236701

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8139010-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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