Article
Fusogenic selectivity of the envelope glycoprotein is a major determinant of human immunodeficiency virus type 1 tropism for CD4+ T-cell lines vs. primary macrophages.
Proceedings of the National Academy of Sciences of the United States of America - 12 Sept 1995
Broder C C, Berger E A
Abstract excerpt
We investigated the relationship between the fusion selectivity of the envelope glycoprotein (env) and the tropism of different human immunodeficiency virus type 1 (HIV-1) isolates for CD4+ human T-cell lines vs. primary macrophages. Recombinant vaccinia viruses were prepared encoding the envs from several well-characterized HIV-1 isolates with distinct cytotropisms. Cells expressing the recombinant envs were...
Topics
- CD4-Positive T-Lymphocytes
- Cells, Cultured
- Genetic Variation
- HIV-1
- Humans
- Macrophages
- Recombinant Proteins
- Vaccinia virus
- Viral Fusion Proteins