Article
Enhanced fusion and virion incorporation for HIV-1 subtype C envelope glycoproteins with compact V1/V2 domains.
Journal of virology - 1 Feb 2014
Cavrois Marielle, Neidleman Jason, Santiago Mario L, Derdeyn Cynthia A, Hunter Eric, Greene Warner C
Abstract excerpt
In infected people, the HIV-1 envelope glycoprotein (Env) constantly evolves to escape the immune response while retaining the essential elements needed to mediate viral entry into target cells. The extensive genetic variation of Env is particularly striking in the V1/V2 hypervariable domains. In this study, we investigated the trade-off, in terms of fusion efficiency, for encoding V1/V2 domains of different...
Topics
- Base Sequence
- Cloning, Molecular
- DNA Primers
- Enzyme-Linked Immunosorbent Assay
- Genetic Engineering
- Genetic Variation
- HIV-1
- Humans
- Molecular Sequence Data
- Protein Structure, Tertiary
- Sequence Alignment
- Sequence Analysis, DNA
- Virus Integration
- env Gene Products, Human Immunodeficiency Virus