Article
Glutathione S-transferase genotype and p53 mutations in adenocarcinoma of the small intestine.
Scandinavian journal of gastroenterology - 1 Aug 2003
Nørum Pedersen L, Kaerlev L, Stubbe Teglbjaerg P, Olsen J, Eriksson M, Guenel P, Ahrens W, Ballard T, Autrup H
Abstract excerpt
Adenocarcinoma of the small intestine (ASI) is a rare disease of unknown aetiology. The glutathione S-transferase M1 (GSTM1) enzyme catalyses the detoxification of compounds involved in carcinogenesis of adenocarcinoma of the stomach, colon and lung, including constituents of tobacco smoke. We investigated a possible interaction between the lack of GSTM1 enzyme activity and the carcinogenic compounds of tobacco...
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