Article
Relevance of GSTM1, GSTT1, and GSTP1 gene polymorphisms to gastric cancer susceptibility and phenotype.
Mutagenesis - 1 Nov 2012
García-González M Asunción, Quintero Enrique, Bujanda Luis, Nicolás David, Benito Rafael, Strunk Mark, Santolaria Santos, Sopeña Federico, Badía María, Hijona Elizabeth, Pérez-Aísa M Angeles, Méndez-Sánchez Isabel M, Thomson Concha, Carrera Patricia, Piazuelo Elena, Jiménez Pilar, Espinel Jesús, Campo Rafael, Manzano Marisa, Geijo Fernando, Pellisé Maria, González-Huix Ferrán, Espinós Jorge, Titó Llusia, Zaballa Manuel, Pazo Roberto, Lanas Angel
Abstract excerpt
Human glutathione S-transferases (GSTs) are phase II metabolizing enzymes that play a key role in protecting against cancer by detoxifying numerous potentially cytotoxic/genotoxic compounds. The genes encoding the human GST isoenzymes GSTM(mu)1, GSTT(theta)1 and GSTP(pi)1 harbour polymorphisms, which have been considered important modifiers of the individual risk for environmentally induced cancers such as...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
